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The hydrolytic cleavage of its 6-nitro-2,3-dihydroimidazo [2,1-b] oxazole moiety generates M1, which undergoes further transformations involving hydroxylation and oxidation, mediated largely by CYP3A4 (Szumowski and Lynch, 2015

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adults over the past half century: an estimated 14.0% of U.S

China consumes more than one-third of the world's cigarettes and has one-sixth of the global smoking death toll