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Anderson, R., Groundwater, P

doi: 10.1139/bcb-2019-0117 189 RodriguesBGoyalRKMcNeillJH

These components are considered immunological distractors with pro-inflammatory activity, capable of causing dysbiosis and increased intestinal permeability (the so-called leaky gut syndrome), so favoring the development of autoimmune diseases [142]

In the cellular environment, the production of H 2 S is clearly detectable in cells and tissues that express CBS

doi: 10.1007/s00018-020-03459-1

Notably, both DFO and ammonium ferric citrate enhance erastin-induced cell death, implying that although systemic iron overload exists in FRDA, cytosolic iron may still be limiting, and iron metabolism is dysregulated, contributing to cellular vulnerability