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Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

Low-dose X-ray irradiation enhances NTR activity, resulting in increased protein labeling and DNA damage, as well as the induction of robust ICD

Unlike many antioxidants, ALA is both water- and fat-soluble, allowing it to work throughout the body more effectively

Curr Opin Gastroenterol 34:2530

L-PAM as a single agent was highly active against MM.1S, KMS-12-PE, MOLP-2 and NCI-H929, inducing 2 logs of cell kills at the maximum dose (50 M)

Moreover, excess iron could promote the formation of reactive oxygen species (ROS), which can lead to oxidative stress and DNA damage, with cytokine-regulated inflammatory pathways and a central contribution from innate immune cells in the tumor microenvironment (360, 361)