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Frederick Allen before the advent of medical insulin, we see that they were only able to keep patients alive for months, sometimes more than a year, by Joslin proudly wrote that, Whereas formerly the prognosis for children less than 10 years of age was measured in months, today it is rare for a child to live for less than one year. Ultimately, all of Joslins pre-insulin patients died

Cell metabolism , 27 3, 529-547

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