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2a) in agreement with previous measurement of the MT3 transcript in MS 24

Importantly, these epigenetic alterations have been shown to persist beyond the period of active androgen exposure, even after partial normalisation of circulating hormone levels

Rahim M, Jan N, Khan S, Shah H, Madni A, Khan A, et al

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When storage capacity is exceeded, excess fatty acids spill into the circulation, accumulate in non-adipose tissues, and promote lipotoxic pathology (98, 99)