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Once released in the cytosol active p53 induces cellintrinsic apoptosis by activating a caspasedependent pathway likely involved in previously reported transcriptionindependent p53mediated apoptosis at the mitochondria Effectively, FOXO4-DRI is able to selectively penetrate the senescent cells without targeting healthy cells due to the use of D-amino acids instead of L-amino acids

Notably, serum nitrates and nitrites, indicators of NO production, increased significantly after blueberry juice consumption (Stote et al., 2017)

These results suggest that DUSP1 downregulation is associated with the pathogenesis of diabetic nephropathy

A 2021 review found that the pigment may help with several biological functions, including protecting cardiovascular health

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