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The deleterious polymorphisms of gene and their impact on function of protein, association and linkage of selected gene polymorphisms of the glutathione S-reductase ( GSR ) with various defects/disorders like Obstructive Heart Defects (OHDs)) and hereditary anaemia in humans is also presented here

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Relative to cell growth and death and aging, ferroptosis had the highest enrichment score (Additional file 2: Figure S1)

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This dual exploitation creates multiple therapeutic opportunities: disrupting cancer cell metabolism, inducing alternative cell death pathways, and modulating the immune microenvironment