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A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation

This loss of DA causes a deregulation in the basal ganglia circuitries that leads to the appearance of motor symptoms such as bradykinesia, resting tremor, rigidity, and postural instability as well as non-motor symptoms such as sleep disturbances, depression, and cognitive deficits (Rodriguez-Oroz et al., 2009)

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101 It seems reasonable to speculate that diabetes-associated hyperglycemia and high-glucose diet might promote tumor development by upregulating the protein acetylation described above