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Methylmalonic acid (MMA) is an intermediary molecule in the mitochondria which builds up as B12 levels drop and spills out into the urine and blood, indicating a relatively low B12 level

Finally, poor oral bioavailability, incomplete toxicology, uncertain long-term effects, and the absence of controlled human trials remain major limitations

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In one study, AOD-9604 was shown to improve joint function and reduce pain in patients with osteoarthritis

Consider B 12 supplementation without testing in asymptomatic patients with risk factors for B 12 deficiency (see Table 1: Patient Risk Factors Associated with B 12 Deficiency)

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