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(2022) 7:e10276

The most common chemical reaction performed by CYP450 enzymes is oxidation, which requires a steady supply of molecular oxygen and an electron transport system to function

Stiripentol, an LDH inhibitor, has been shown to significantly boost the effectiveness of TMZ through a mechanism that involves modulating lactylation [161]

Available online: 38.Hu K., Ding P., Wu Y., Tian W., Pan T., Zhang S

The main difference is bioavailability at the target tissue

One major issue is difficulty in attributing mechanisms: It remains unclear whether their neuroprotective effects arise specifically from ferroptosis inhibition or indirectly through anti-inflammatory, anti-aggregation, or mitochondrial protective pathways, and genetic evidence is lacking (e.g., validation in GPX4 conditional knockout models)