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Crivellato E, Candussio L, Rosati AM, Decorti G, Klugmann FB, Mallardi F (1999) Kinetics of doxorubicin handling in the LLC-PK1 kidney epithelial cell line is mediated by both vesicle formation and P-glycoprotein drug transport

However, an RCT on 35 patients with migraine, showed that supplementation with N-acetylcysteine (1,200 mg), vitamin E (500 IU), and vitamin C (1,000 mg) daily for 3 months resulted in lower frequency, severity, and duration of headaches and lower acute medication use (90)

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The resulting tryptic peptides were desalted using in-house-crafted SDB-RPS StageTips and 200 ng of peptides were loaded in Evotips (Evosep) according to the manufacturers instructions

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Compared to the standard administration of doxorubicin, the concentration over time of DLE administration was approximately five-fold higher for blood and six-fold higher for plasma (Ataullakhanov et al., 1997)