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Among patients with non-cirrhotic MASH, 6% progressed to compensated cirrhosis within 72 months (Figure 1a)

The glutamatergic neurons of the motor cortex innervate two main types of striatal GABAergic neurons

It has been associated with various neurological conditions, including post-stroke hemorrhage and pulmonary thromboembolism [156, 157]

Accordingly, the present expert panel suggests that DPN should be considered in a patient with prediabetes or diabetes who presents with neuropathic symptoms (involve both sides symmetrically) and/or signs of neuropathy in the presence of DPN risk factors (i.e., advancing age, obesity, hypertension, dyslipidemia, poor glycemic control), with careful consideration of laboratory testing to rule out other causes of distal symmetric peripheral neuropathy and referral for a detailed neurological work-up for a confirmative test of either small or large nerve fiber dysfunction only in atypical cases

Yes, MOTS-c can be safely combined with other peptide therapies, hormone optimization, nutritional interventions, and exercise programs

Intravenous infusions are considered invasive procedures and can come with extra risks such as injection site infections