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albicans were co-infected, a thicker, denser biofilm with stronger tolerance to harmful stresses was formed on root canal dentin and glass slides, which can increase bone resorption of osteoclasts, inhibit the bone formation of osteoblasts, upregulate inflammatory cytokines such as IL-6 and TNF-, and ultimately increase the severity of dental pulp diseases

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[2] Over-the-counter benzoyl peroxide (2.55% preparations) may also be helpful