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However, only some people with the gene develop the condition

Neuropilin, an immunosuppressive surface protein expressed by Tregs that act as VEGF co-receptors, enhances VEGF binding affinity for VEGFRs [88]

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Experiments confirmed that the amino acid sequence LKKTET was responsible for angiogenesis, since mutagenesis of the motif severely decreased the efficiency of T4 in forming vessels