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The efflux of chloride mediated by GABA in immature neurons is excitatory, triggering sodium spikes and activating voltage-gated Ca 2+ channels [1]

As a consequence of the absence of the two enzymes capable of cleaving the glutamyl bond, the strain is deficient in glutathione and glutamyl aminoacid utilization

In this regard, to bring concentration of AFs in spices and herbal products down, taking precautionary actions, such as raising public awareness, might support consumers to purchase healthy and AFs-free products (170, 171)

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Conversely, strategies that allow the spatial activation of enzymes, e.g., light-regulated allosteric switches that control kinase activation optogenetically (Shaaya et al., 2020), may be coupled to PDB