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Interestingly, treating mice with the salvage precursor NR resulted in NAD + repletion in muscle stem cells (MuSCs) of young and aged mice 108

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Given that TGF-1 is upstream of pSmad3C/pSmad3L, the further stimulation of HSC-T6 and HepG2 with TGF-1 can induce Nrf2 inactivation

For estimation of outlier measurements, the cNMF algorithm 65 implemented in SynergyFinder was used

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