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van Eijk et al., 2022)

After seven days of treatment, increases persisted in substantia nigra (both compacta and reticulata), lateral caudate, accumbens nucleus, and superior olive

PilZ domain-containing proteins represent the best-studied class of c-di-GMP effectors

This approach reduces stress and discomfort for the animals while maintaining efficacy

[13] DSS Model Results : Weight loss significantly reduced at day 8 Myeloperoxidase activity (neutrophil marker) dropped 50% Prevented colon weight increase and length decrease IL-6 and IL-12 mRNA expression significantly reduced Histology showed less inflammation, reduced cell damage, fewer inflammatory cells in tissue layers TNBS Model Results (more acute inflammation): Weight loss reduced within 1-2 days post-TNBS Colonic MPO activity decreased 30% Prevented TNBS-induced colon shortening Broad cytokine suppression: IL-1, IL-6, TNF-, IFN- mRNA all reduced KPV didnt affect inflammatory markers in healthy mice