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It was proved that the low melatonin nighttime might intensify the nocturnal pain sensation [19]

Recent research indicates that neuronal ATP and adenosine interact with their respective receptors-P2X and P2Y for ATP, and adenosine A 2A receptors (A 2A R) for adenosine-leading to pericyte contraction, which reduces CBF, or membrane hyperpolarization, which increases CBF [26, 87,88,89]

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The study found that bvPLA2 can improve glucose metabolism and minimize neuroinflammatory reactions in the hippocampus, perhaps limiting AD development (Ye et al., 2016b)

[3] Rim, M