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Weill Cornell Medicine: "Liver Damage Caused by Supplements Is Becoming More Common" LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: " Herbal and Dietary Supplements" Merck Manual: "Overview of Vitamins" Cleveland Clinic: "Toxic Hepatitis (Liver Toxicity)" MedlinePlus: "Vitamins" International Journal of Caring Sciences : "B12 Hypervitaminemia: Pathogenetic Pathways and Clinical Implications" LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: "Vitamin B" Mayo Clinic: "Niacin" LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: " Niacin Nutrients: The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?" Ira Daniel Breite, MD Medical Reviewer Ira Daniel Breite, MD, is a board-certified internist and gastroenterologist

In vitro studies have further demonstrated that activated macrophages secrete MMPs and proinflammatory cytokines, leading to ECM degradation and VSMC apoptosis