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Research has revealed that acute inhibition of the ERK pathway has inconsistent results in inducing depressive-like behavior, and chronic pharmacological inhibition of ERK through repeated infusion of the specific MAPK kinase (MEK) inhibitor U0126 into the hippocampus and mPFC has been shown to cause depressive-like behavior (Einat et al., 2003

Feb 2013;10(2):90-99

Functional interplay between collagen network and cell behavior within tumor microenvironment in colorectal cancer

however, oxidative stress is poorly characterized and their mechanisms of action are not well understood

The bands were visualized by silver staining following the manufacturers instructions

Methods Chemicals INH, RFM, and SLY were purchased from Sigma-Aldrich Co