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Although it is most commonly observed in the legs , it can also affect the arms in some cases

This review encapsulates recent advancements in research, highlighting novel targets and agents, such as natural compounds, synthetic inhibitors, and clinical trial-stage candidates, all centered on ferroptosis strategies, to offer guidance for future therapeutic developments (Table 3)

The expression of SELENOW is correlated with selenium status and appears to be sensitive to low-selenium supply (19, 20)

To achieve quantification and external validation, high-resolution imaging should be paired with mechanical measurements to resolve skin-surface microrelief trajectories and cellECM interaction forces, with standardized QC readouts across barrier function, secretome, and mechanics 131,134

Governments and international organizations must collaborate to develop and implement effective laws and regulations to govern the development of AI and ensure the protection of public interests