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One cited human study found that while no single metabolomic feature could cleanly distinguish malignant from benign lymph nodes, metabolites such as kynurenine and oxidized glutathione differed in aspirates from patients with NSCLC

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In the conserved DXDX(T/V) motif, the first aspartate is the phosphorylated residue in the PMM phosphoenzyme ( Structurally, the PMM enzyme belongs to the haloalkanoic acid dehalogenase (HAD) superfamily (Silvaggi et al., 2006)

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156,157 Therefore, efficient NLRP3 inflammasome inhibitors are novel therapeutic agents for MDD