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Benzodiazepines and Other CNS Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), and other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death

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Phase 2: DMSA orally 250 mg for 3 consecutive days

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44, 131, 132 Infusion of LVV-H7, a more stable ligand with a high affinity ( K i 73 nM) for the AT 4 receptor, but no affinity for AT 1 receptors, 133 failed to alter RBF