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The affinities of these interactions are evolutionarily fine-tuned: strong enough to maintain the kinase in an autoinhibited conformation, yet sufficiently weak to respond to diverse cellular stimuli 22

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In order to confirm whether GMP localizes in the nucleus of cultured neonatal rat cardiomyocytes (NRCMs), the cardiomyocytes were transduced with GMP using a lentiviral vector and subjected to immunocytochemical staining with anti--actin antibody (red signal in Fig

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Therefore, when weight loss is the desired goal, a calorie-restricted diet should be combined with less sedentary time and increased physical activity

These inhibitory auxins were thought to be held mainly by the hydrophilic amino acid residues that are located at the glutathione-binding site of the enzyme