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156 Lysosomal enzymes produce autoantigens, alter the mucosal barrier, and increase cytokine secretions

However, the response is heterogeneous: in some patients, HDL-C levels decrease

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cGAMP binds to and activates the endoplasmic reticulum transmembrane receptor STING, finally resulting in the production and release of type I interferons (IFN), which are potent anti-viral and anti-cancer cytokines (136)

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Results: During this study period, we identified 10,864 patients hospitalized for AH with a median age of 49 years, a MELD score of 22, and a Maddrey score of 38