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1 in 7 adult heart transplant candidates are sensitized, a number that has doubled in the past two decades ( A common sequela of AMR in heart transplantation is cardiac allograft vasculopathy (CAV), and in lungs, chronic lung allograft dysfunction (CLAD), both of which result in significant mortality and morbidity within 5 years of transplantation ( Shifting Toward Sensitization As mentioned, use of mechanical support as bridge to transplantation has been steadily increasing, reaching 50% of patients on the waiting list for heart transplant in 2013

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