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GBM growth driven by neuronal activity can be regulated by some factors such as synaptic adhesion molecule neuroligin-3, brain-derived neurotrophic factor (BDNF) [288] or through neurotransmitter receptors like glutamatergic excitatory synapses (interacting with astrocytes) [287, 289, 290], dopaminergic receptors (D2 and D4 subtypes) [291], and -aminobutyric acid (GABA) receptors [292, 293]