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Further adjustments for body mass index, hypertension, diabetes mellitus, smoking status, alcohol intake, and history of stroke did not appreciably change these results (RR for all-cause dementia, 0.54 [95% CI, 0.29-0.98

Cell Longev 2019, 9084643

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39.9% with placebo), with nausea, vomiting, and diarrhea peaking during dose escalation and declining thereafter, whereas constipation remained relatively constant