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Exposure of recombinant CD38 + cells to isatuximab produced near-complete inhibition of the CD38 cyclase activity in a dose-dependent manner, while both a surrogate antibody for daratumumab (produced based on published sequences and thus potentially not completely identical to the original antibody) and daratumumab resulted in a much lower inhibition [19, 21, 22]

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In such cases, findings like hypercellularity, increased erythroblasts, or cytogenic abnormalities might misleadingly suggest leukemia, leading to extensive workup and aggressive treatment measures ( Figures 2A, B were consistent with similar cases in the literature

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