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Symptoms of such an extreme over-dose can include increased fatigue, joint or muscle pain, skin rashes, photosensitivity, irritability, paresthesia, dizziness, sleep disturbances, asthenia, muscle cramps, night sweats, hypertension, hypotension, headaches (especially migraines) and swollen glands

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FDX, as an electron donor, engages in various metabolic processes due to its versatile nature, which include participation in the synthesis of steroids, hemoglobin, vitamin D, and the biogenesis of Fe-S clusters in different organisms

The gyrA D94G substitution is a key marker of high-level FQ resistance, as these mutations reduce drug binding affinity (Miotto et al., 2024)

Abstract Ferroptosis is a recently recognized form of non-apoptotic regulated cell death and usually driven by iron-dependent lipid peroxidation and has arisen to play a significant role in cancer biology