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Copper toxicosis, due to failure to transport this metal into the biliary canaliculus, is the mechanism of liver damage in Wilson disease, a genetic disease caused by a loss-of-function mutation in the ATP7B gene

Thereafter, the nerves of the base of the skull were carefully and obtusely peeled off utilizing ophthalmic forceps, and the whole brain tissues were taken out and put into the glass dish lined with tinfoil at 4C, followed by the subsequent operations conducted on ice

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doi: 10.1074/jbc.R113.455311

Takeda, T.A., et al.,Continuous de novo biosynthesis of haem and its rapid turnover to bilirubin are necessary for cytoprotection against cell damage

In addition, long-term efficacy and safety were not evaluated in mammalian AD models