Melatonin production in an aerobic photosynthetic bacterium: an evolutionarily early association with darkness
DeepContrast can be retroactively applied to these data and can be used to generate synthetic functional maps, significantly expanding pathophysiological insight that can be derived across a range of disorders
The presence of funnel plot asymmetry also suggests potential publication bias, which warrants further scrutiny
Glossary ABH 2(S)-amino-6-hexanoic acid ACh acetylcholine ADMA asymmetric dimethylarginine Akt protein kinase B AMPK AMP-activated protein kinase ASL argininosuccinate lyase ASS argininosuccinate synthase BEC S-(2-boronoethyl)-l-cysteine BH 2 dihydrobiopterin BH 4 tetrahydrobiopterin CAD Coronary Artery Disease CaM calmodulin CaMKII calcium/calmodulin-dependent protein kinase II CAT-1 cationic amino acid transporter-1 Cav-1 caveolin-1 cGMP cyclic GMP CSD caveolin-scaffolding domain CVD cardiovascular disease CytB5R3 cytochrome b5 reductase 3 DHFR dihydrofolate reductase Dyn2 dynamin-2 ECs endothelial cells EDD end-diastolic diameter eNOS endothelial nitric oxide synthase FAD flavin adenine dinucleotide FMD% flow-mediated dilation percentage FMN flavin mononucleotide GPCR G-protein coupled receptor Grx1 glutaredoxin GSH reduced glutathione GSSG oxidized glutathione GTPCH guanosine triphosphate cyclohydrolase I Hb alpha subunit of hemoglobin HDL high-density lipoprotein HIF-1 hypoxia-inducible factor-1 alpha Hsp90 heat shock protein 90 ICAM-1 intracellular adhesion molecule 1 iNOS inducible NOS KLF2/KLF4 Krppel-like factor 2/Krppel-like factor 4 LAD left anterior descending coronary artery lncRNAs long non-coding RNAs LPS lipopolysaccharide MEJ myoendothelial junctions MI myocardial infarction METHF 5-methyltetrahydrofolate NADPH nicotinamide adenine dinucleotide phosphate NF-B nuclear factor kappa-light-chain-enhancer of activated B cells nNOS neuronal NOS NO nitric oxide NOHA N-hydroxy-L-arginine nor-NOHA N-hydroxy-nor-L-arginine NOS NO synthases NOSIP eNOS interacting protein NOSTRIN eNOS trafficking inducer NOX 2 NADPH oxidase 2 Nrf2 nuclear factor erythroid 2-related factor ox-LDL oxidized low-density lipoprotein PAH pulmonary arterial hypertension PDE phosphodiesterase PKA protein kinase A PKG protein kinase G PMCA plasma membrane Ca 2+ -ATPase PPIs protein-protein interactions PTMs post-translational modifications ROS reactive oxygen species sGC soluble guanylate cyclase SIRT1 sirtuin 1 SMAD2 mothers against decapentaplegic homolog-2 SNOs s-nitrosothiols SOCE store-operated Ca 2+ entry Sp1 specificity protein 1 Sp3 specificity protein 3 STIM1 stromal interaction molecule 1 T1D type 1 diabetes T2D type 2 diabetes TAC transverse aortic constriction TGF- tumor growth factor-beta TNF- tumor necrosis factor-alpha VEGF vascular endothelial growth factor VSMCs vascular smooth muscle cells References 1 AbdullaevI
Recently, ergothioneine received self-affirmed Generally Recognized As Safe (GRAS) and approval as a food supplement by the European Food Safety Authority (EFSA) [13], which led it to be a promising new functional food nutritive fortifier
this is also the pathway that is induced by glutamate interacting with the Xc system to produce toxicity
