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While the exact causes remain unclear, potential contributors include environmental pollution, endocrine disruptor chemicals (EDCs) and oxidative stress, with the latter becoming a growing concern

Zeariya School of Public Health, Huazhong University of Science and Technology, Wuhan, China Haijun Zhang Department of International Health, Johns Hopkins University, Baltimore, MD, USA Haijun Zhang School of Public Policy and Administration, Xi an Jiaotong University, Xian, China Jingya Zhang School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China Bin Zhu Department of Biochemistry and Pharmacogenomics, Medical University of Warsaw, Warsaw, Poland Magdalena Zieliska Clinical Research Centre, An-Najah National University Hospital, Nablus, Palestine Saed H

Hypothetically, elevated ROS on a high glucose diet may induce detoxifying genes, which would render animals more resistant to oxidative stress

Nature 295 , 667671 (1982)

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