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SehrawatACroixCSBatyCJWatkinsSTailorDSinghRPet al

5 , e101999 (2014)

154 Protein denaturation is a biochemical process that disrupts the hydrogen, hydrophobic, and disulfide bonds, which leads to alteration in the structure of the protein

One successful example from another field is oral bile acid supplements for certain neurological disorders

Given this extremely large reductive cost to methionine synthesis, cells appear to gauge methionine availability as an indicator of NADPH availability, and of overall reductive biosynthetic capacity