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Research and clinical experience demonstrate that PT-141 can: Improve sexual desire in men with low libido regardless of testosterone status Provide benefit for men with erectile dysfunction who respond incompletely to PDE-5 inhibitors Address the psychological and desire-related components of ED that vascular medications cannot reach Work through a non-hormonal, non-androgen pathway an option for men who cannot use testosterone therapy Clinical Research in Men Early clinical studies demonstrated statistically significant erectile response in men receiving PT-141 compared to placebo, with first erection occurring approximately 30 minutes after administration

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Alternatively, female and male mice may experience different forms of life stress that may act upon SUMOylation pathways