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methodology and software: S.B.A

Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green

It also prevents the oxidative damage that can be caused by exposure to sunlight

This is exactly where antioxidants for mental health come into play

Finally, in order to enhance the efficacy of therapeutic agents, it is crucially important to develop drug delivery systems that enable supersulfide donors to target affected areas