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Produces a depletion of releasable CNS neuronal monoamine neurotransmitters Indications: Tardive dyskinesia tardive dyskinesia is a neurological disorder characterized by involuntary movements believed to be caused by dopamine hypersensitivity, and which is associated with the long-term use of antipsychotic drugs that antagonize dopamine receptors

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TB-500 operates primarily through G-actin sequestration, PI3K/Akt pathway activation, and promotion of endothelial cell and fibroblast migration , producing particularly pronounced effects on angiogenesis, cell migration into wound beds, cardiac and skeletal muscle repair, and the remodelling of extracellular matrix during tissue regeneration

However, the authors reported some cases in which low-dose prednisone can have a major effect on quality of life, particularly in older adults

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Heart Failure , 11 (2), e004519