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NADPH is required to restore resultant GSSG to active GSH

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Results showed that 17 of 27 indole derivatives could inhibit DNMT1 with an IC 50 of 50 M or less

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Simultaneously, the activation of plaque macrophages by CD4 + T lymphocytes through CD40LCD40 signaling amplifies pro-inflammatory cytokine secretion, promotes macrophage polarization towards the M1 phenotype, and recruits immune cells, collectively perpetuating plaque instability