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These factors promote the activation of fibroblasts and the excessive production of ECM components

Targeting thioredoxin reductase by eupalinilide B promotes apoptosis of colorectal cancer cells in vitro and in vivo

Current therapies include ERT to compensate for the missing or defective enzyme, and substrate reduction therapy to reduce the accumulation of toxic substances by limiting their production

Afterwards, a second incubation was made under the previous conditions

doi: 10.1097/bor.0000000000000373 35

Using immunofluorescence and taking advantage of the HA-tag that marks the transformed cells (Methods), we confirmed the presence of this Clu+/HA+ astrocytic glioma cell population in Notch tumors, while Clu was only seen in HA-negative tumor-associated, untransformed astrocytes in the p53 model (Fig