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98 Recently, inhibition of DJ-1 (also known as PARK7-parkinsonism-associated deglycase) has been shown to enhance the sensitivity of tumor cells to ferroptosis induced by sorafenib and evaluated the antitumor activity of erastin in a xenograft nude mouse model via inhibition of the transsulfuration pathway and limiting the supply of cysteine

Mandal, K

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This concentration dependence could reflect the intermolecular nature of the rate-limiting propagation step of lipid autoxidation

2009;4:e6344

Structural studies reveal that full-length human RAGE has three domains (Figure 4): an extracellular part responsible for ligand binding, a hydrophobic transmembrane spanning region, and a highly charged cytoplasmic tail, which is essential for RAGE ligand-mediated signal transduction (83, 87)