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PloS One , 13 (6), e0198626

Additionally, the TME contributes to resistance through hypoxia-induced metabolic reprogramming and immunosuppressive signalling, further complicating therapeutic efforts [197,198,199]

ROS alters the redox status of the affected proteins through the oxidation of methionine residues and thiol groups in cysteine, which eventually influences the signalling processes

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