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Klutstein M, Nejman D, Greenfield R, Cedar H

Curcumin upregulates PGC-1 via AMPK signaling, subsequently enhancing PPAR activity and Superoxide Dismutase-2 (SOD-2) transcription/activity, thereby suppressing 1(I) collagen expression in cultured HSCs (Zhai et al., 2015)

Studies on gut microbiota transplantation in animals confirmed that dysbiosis may increase thyroid autoimmunity susceptibility [179]

Medical physics 50(1):323-329, 2023

This mechanism not only reshapes the immunosuppressive state of the tumor microenvironment but also provides key targets for breaking immune tolerance and improving the efficacy of immunotherapy