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These second messengers, particularly cAMP, may activate protein kinases, enzymes considered responsible for phosphorylating target proteins

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Adapted from a Harvard Health Blog post by Patrick Skerrett

Further studies showed that CDC appears to be a more prominent effector mechanism for daratumumab [22, 28], with evidence suggesting that isatuximab induces CDC only in the presence of high CD38 receptor density [24, 32]

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