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Research based on population studies has shown that structural abnormalities in this crucial vascular junction can lead to reduced cerebral blood flow and damage to the blood-brain barrier

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Annu Rev Neurosci 32: 149184 Kuhnert F, Mancuso MR, Shamloo A, Wang HT, Choksi V, Florek M, Su H, Fruttiger M, Young WL, Heilshorn SC, Kuo CJ (2010) Essential regulation of CNS angiogenesis by the orphan G proteincoupled receptor GPR124