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Animal toxicology signals Two animal findings reviewed by FDA are worth tracking even if they did not surface clinically

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Their results revealed that decreasing NNMT expression in primary hepatocytes led to a reduction in the expression of phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose-6-phosphatase (G6pc), resulting in decreased glucose output

10.1038/s41573-019-0017-4 127 ShiL.LiuX.-Y.HuangZ.-G.MaZ.-Y.XiY.WangL.-Y.et al (2019)

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Can intravenous B12 therapy be used, and when is it indicated