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Dietary supplementation of the cis -MUFA oleic acid (present in olive oil), which upregulates lipid droplets and extends lifespan, also reduced lipid oxidation in middle-aged adults (Fig

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This mechanism represents a control of the influx of fatty acyl units into mitochondria in response to the intra-mitochondrial acetyl-CoA level, in addition to the finely regulated mechanism of CPT1 by malonyl-CoA

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