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Engineered histidine-rich peptides enhance endosomal escape for antibody-targeted intracellular delivery of functional proteins

Its mature domain binds and activates the type 1 IGF receptor (IGF-1R), triggering the canonical downstream cascades principally the PI3K/Akt/mTOR axis that governs protein synthesis and the Ras/ERK axis associated with proliferation

Pharmacodynamics, pharmacokinetics, and cell signaling pathways of pomegranate peel extract

(2013) The effects of daily coenzyme Q10 supplementation on VO2 max, vVO2 max and intermittent exercise performance in soccer players

HZ: Methodology, Project administration, Writing original draft

Using human brain organoid models derived from induced pluripotent stem cells (iPSCs) with targeted knockout of the CNTNAP2 gene, which is associated with autism spectrum disorder (ASD), it was revealed that CNTNAP2-deficient brain organoids exhibit abnormalities such as accelerated cell cycle, increased cortical folding, disrupted glutamatergic/GABAergic synaptic pathways, and upregulation of AKT/mTOR signaling (106)