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The in vivo rat wound-chamber data, in which injected GHK-Cu increased connective-tissue accumulation in a concentration-dependent way while an inactive control peptide did not, are the systemic-route corroboration of these culture findings and are important because they show the effect surviving the transition from a dish to a living animal

The tripeptide has been shown in cell culture and animal models to prolong the anagen phase, giving follicles more time to produce mature, pigmented hair shafts