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Brain, brown fat, and skeletal muscle are among the tissues that contain deiodinase type 2 (DIO2), an enzyme that converts T4 to T3 on a local level

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Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

Due to higher UGT1A3 expression in htgUGT1A -WT animals potentially leading to increased glucuronidation of FXR-inducing bile acids, unaffected UGT1A3 activity is suggested to reduce FXR activation leading to an impaired FXR-induced PPAR-mediated fatty acid oxidation

SLU-PP-332 Dosing Protocol & Schedule Before any numbers: every published in-vivo dose for SLU-PP-332 is a mouse dose

Henrotin Y, Deberg M, Mathy-Hartert M, Deby-Dupont G