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[16] In Phase III, metabolites are transported and excreted from the body

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Risk factors associated with WD cirrhosis Age at diagnosis had 89.5% sensitivity, 69.0% specificity, and an AUC of 0.802 (95% CI: 0.6790.926) for diagnosing WD cirrhosis, with a cut-off value of 22 years old

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In addition, AMPK inhibits the synthesis of fatty acids and increases their degradation by increasing the expression of malonyl-CoA which inhibits fatty acid oxidation (Steinberg and Carling 2019)

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Similar to isotretinoin, there is a risk of teratogenicity with vitamin A

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doi: 10.1016/0024-3205(95)02302-x 153 MateenSRehmanMTShahzadSNaeemSSFaizyAFKhanAQet al

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Dudeja V, Skube S, Chugh R, Yokoyama Y, Borja-Cacho D, Antonoff MB , Dawra RK, Vickers SM, Saluja AK

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